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Unlike native IGF-1, which is released from IGFBP complexes in a regulated fashion at specific tissue sites, IGF-1 LR3 circulates freely and activates IGF-1 receptors throughout the body

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In early pharmacological research, ipamorelin was characterized as one of the first growth hormone secretagogues to stimulate GH release from pituitary cells without producing significant increases in ACTH, cortisol, or prolactin, as seen with earlier-generation compounds like GHRP-6 a selectivity profile documented in the compound’s original pharmacological studies

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